| 產(chǎn)品編號 | bs-7096R |
| 英文名稱 | ARTS/SEPT4 Rabbit pAb |
| 中文名稱 | 凋亡相關(guān)蛋白TGFb信號抗體 |
| 別 名 | Apoptosis Related Protein TGFb Signalling; Apoptosis-related protein in the TGF-beta signaling pathway; ARTS; bradeion; Bradeion beta; Brain protein H5; CE5B3; CE5B3 beta; cell division control-related protein 2; cerebral protein 7; H5 antibody hCDCREL-2; hucep-7; peanut-like 2; Peanut-like protein 2; PNUTL2; SEPT4; SEPT4_HUMAN; septin 4; Septin-4. |
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Specific References (2) | bs-7096R has been referenced in 2 publications.
[IF=5.572] Miao Song. et al. Mitophagy alleviates AIF-mediated spleen apoptosis induced by AlCl3 through Parkin stabilization in mice. FOOD CHEM TOXICOL. 2023 Jun;176:113762 WB ; Mouse.
[IF=4.556] Xiaoning Zhang. et al. Cabs1 Maintains Structural Integrity of Mouse Sperm Flagella during Epididymal Transit of Sperm. Int J Mol Sci. 2021 Jan;22(2):652 WB,IHC ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)胞凋亡 細(xì)胞周期蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 55 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ARTS: 91-150/478 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene is a member of the septin family of nucleotidebinding proteins, originally described in yeast as cell divisioncycle regulatory proteins. Septins are highly conserved in yeast,Drosophila, and mouse, and appear to regulate cytoskeletalorganization. Disruption of septin function disturbs cytokinesisand results in large multinucleate or polyploid cells. This gene ishighly expressed in brain and heart. Alternatively splicedtranscript variants encoding different isoforms have been describedfor this gene. One of the isoforms (known as ARTS) is distinct; itis localized to the mitochondria, and has a role in apoptosis andcancer. [provided by RefSeq, Nov 2010]. Function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Subunit: Septins polymerize into heterooligomeric proteincomplexes that form filaments, and can associate with cellularmembranes, actin filaments and microtubules. GTPase activity isrequired for filament formation (By similarity). Interacts withSEPT8. In a mesenchymal cell line, interacts with SEPT9 isoform 2variants HNA Trp-106 and Phe-111, but not the wild type SEPT9.Isoform ARTS, but no other isoforms, interacts with XIAP after theinduction of apoptosis. Subcellular Location: Cytoplasm (By similarity). Cytoplasm,cytoskeleton (By similarity). Note=In platelets, found in areassurrounding alpha-granules. Isoform ARTS: Mitochondrion. Nucleus.Note=While predominantly localized in the mitochondria underresting conditions, isoform ARTS translocates into the nucleusafter TGF-beta treatment and apoptosis induction. Tissue Specificity: Widely expressed in adult and fetal tissueswith highest expression in adult brain (at protein level), heart,liver and adrenal gland and fetal heart, kidney, liver and lung.Also expressed in colorectal cancers and malignant melanomas.Expressed in platelets. Post-translational modifications: N-glycosylated. Similarity: Belongs to the peptidase M1 family. SWISS: O43236 Gene ID: 5414 Database links: Entrez Gene: 5414 Human Entrez Gene: 18952 Mouse Omim: 603696 Human SwissProt: O43236 Human SwissProt: P28661 Mouse Unigene: 287518 Human Unigene: 2214 Mouse Unigene: 6269 Rat |
