| 產(chǎn)品編號(hào) | bs-12067R |
| 英文名稱 | TLX2 Rabbit pAb |
| 中文名稱 | T淋巴細(xì)胞白血病同源蛋白2抗體 |
| 別 名 | Enx; homeo box 11 like 1; Homeobox protein Hox 11L1; Homeobox TLX 2; HOX11L1; NCX; Neural crest homeobox protein; PMUR10F; T cell leukemia homeobox protein 2; T cell leukemia, homeobox 2. |
| 研究領(lǐng)域 | 腫瘤 神經(jīng)生物學(xué) 細(xì)胞分化 淋巴細(xì)胞 t-淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human,Rat (predicted: Mouse,Rabbit,Pig,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 30 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TLX2: 101-200/284 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
T-cell leukemia homeobox protein 2 (TLX2), also known as homeobox protein Hox-11L1 (HOX11L1), neural crest homeobox protein (NCX) or ENX, is a 284 amino acid member of the TLX homeobox family. The mouse homolog, Tlx2, has been detected in dorsal-root ganglia, cranial and entric-nerve gangla, parasympathetic ganglia and adrenal glands in mouse embryos and in the adrenal glands, intestine and heart of adult mice. The expression pattern of Tlx2, which is restricted to tissues derived from nerual crest cells, suggests that it may play a role in the proliferation or differentiation of the enteric peripheral nervous system. TLX2, which is localized to the nucleus, is highly homologous to mouse Tlx2, and shares several critical domains, including an enhancer element in the promotor that is crucial for tissue-specific expression. Mutations in the gene encoding mouse Tlx2 lead to congenital anomalies closely resembling neuronal intestinal dysplasia in humans. Thus, TLX2 is thought to play a role in this disease, which is a rare condition characterized by hyperplasia of submucosal plexus with giant submucosal ganglia and increased acetylcholinesterase activity in nerve fiber around submucosal blood vessels. Function: TLX2 contains 1 homeobox DNA-binding domain and the function remains unknown. In the mouse, this gene is expressed from embryonic day 9.5 through day 13.5 and is detectable in the dorsal root ganglia, cranial and enteric nerve ganglia and adrenal glands. In adult animals its expression is limited to the adrenal gland and the intestine. TLX2 may be involved in the proliferation and/or differentiation of enteric peripheral nervous system. Subcellular Location: Nuclear Similarity: Contains 1 homeobox DNA-binding domain. SWISS: O43763 Gene ID: 3196 Database links: Entrez Gene: 3196 Human Entrez Gene: 21909 Mouse Omim: 604240 Human SwissProt: O43763 Human SwissProt: Q61663 Mouse |
| 產(chǎn)品圖片 |
Sample:HepG2 (Human)CellLysate at 40 ug
Primary: Anti-TLX2(bs-12067R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 30kD
Observed band size: 30kD
Sample:Cerebrum (Rat)Lysate at 40 ug
Primary: Anti-TLX2(bs-12067R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 30kD
Observed band size: 30kD
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